全文获取类型
收费全文 | 1566篇 |
免费 | 56篇 |
国内免费 | 49篇 |
专业分类
系统科学 | 15篇 |
丛书文集 | 50篇 |
教育与普及 | 13篇 |
理论与方法论 | 6篇 |
现状及发展 | 174篇 |
研究方法 | 3篇 |
综合类 | 1409篇 |
自然研究 | 1篇 |
出版年
2024年 | 2篇 |
2023年 | 7篇 |
2022年 | 22篇 |
2021年 | 19篇 |
2020年 | 17篇 |
2019年 | 18篇 |
2018年 | 20篇 |
2017年 | 27篇 |
2016年 | 20篇 |
2015年 | 32篇 |
2014年 | 55篇 |
2013年 | 38篇 |
2012年 | 71篇 |
2011年 | 68篇 |
2010年 | 44篇 |
2009年 | 55篇 |
2008年 | 83篇 |
2007年 | 84篇 |
2006年 | 76篇 |
2005年 | 83篇 |
2004年 | 67篇 |
2003年 | 87篇 |
2002年 | 64篇 |
2001年 | 58篇 |
2000年 | 66篇 |
1999年 | 62篇 |
1998年 | 59篇 |
1997年 | 42篇 |
1996年 | 40篇 |
1995年 | 31篇 |
1994年 | 36篇 |
1993年 | 23篇 |
1992年 | 28篇 |
1991年 | 25篇 |
1990年 | 35篇 |
1989年 | 21篇 |
1988年 | 18篇 |
1987年 | 18篇 |
1986年 | 14篇 |
1985年 | 26篇 |
1984年 | 10篇 |
排序方式: 共有1671条查询结果,搜索用时 203 毫秒
1.
Hunt MC Greene S Hultenby K Svensson LT Engberg S Alexson SE 《Cellular and molecular life sciences : CMLS》2007,64(12):1558-1570
Acyl-CoA thioesterases (ACOTs) catalyze the hydrolysis of acyl-CoAs to free fatty acids and coenzyme A. Recent studies have
demonstrated that one gene named Acot7, reported to be mainly expressed in brain and testis, is transcribed in several different isoforms by alternative usage of
first exons. Strongly decreased levels of ACOT7 activity and protein in both mitochondria and cytosol was reported in patients
diagnosed with fatty acid oxidation defects, linking ACOT7 function to regulation of fatty acid oxidation in other tissues.
In this study, we have identified five possible first exons in mouse Acot7 (Acot7a–e) and show that all five first exons are transcribed in a tissue-specific manner. Taken together, these data show that the
Acot7 gene is expressed as multiple isoforms in a tissue-specific manner, and that expression in tissues other than brain and testis
is likely to play important roles in fatty acid metabolism.
Received 5 February 2007: received after revision 3 April 2007; accepted 19 April 2007 相似文献
2.
3.
用血管铸型和透明方法观察了家兔膀胱的血供情况。膀胱动脉主要起自脐动脉,沿膀胱侧缘行向膀胱顶,沿途发出1~4支基本对称的分支分布于膀胱前面,两侧膀胱动脉的分支在其表面有吻合现象。膀胱动脉及其分支均呈不同程度的弯曲或弹簧状,可能是适应膀胱生理性增大的结构基础。 相似文献
4.
5.
J. W. Faigle H. Stierlin H. Mory T. Winkler H. -P. Kriemler 《Cellular and molecular life sciences : CMLS》1985,41(4):476-478
Summary Indoxyl derivatives were detected as minor products among the urinary metabolites of two trial drugs, a benzodiazepine (GP 55 129) and a benzophenone (CGP 11 952). Their structures were elucidated by NMR and mass spectroscopy. Presumably, metabolites containing potential aldehyde functions react spontaneously with endogenous indoxyl. Such derivatives have not hitherto been encountered in drug metabolism. 相似文献
6.
排球运动中的供能特点与营养补充 总被引:3,自引:0,他引:3
物质和能量代谢是人体各组织器官机能活动的基础,应用运动时物质和能量代谢规律指导训练期间的营养安排是非常有益的.通过对排球运动的特点进行分析,结合各供能系统的特点以及各种能量物质分解的先后关系,简要陈述排球比赛中的物质和能量代谢,分析了排球运动中疲劳产生的可能原因,有针对性地提出训练中的营养安排以及应当注意补充的几种营养物质。 相似文献
7.
统计分析在血铅检测中的应用 总被引:1,自引:0,他引:1
该文针对河海大学幼儿园接受血铅调测的337名幼儿,以对家长问卷调查的方式,运用方差分析、假设检验及区间估计的方法对这些幼儿的血铅超标情况进行了统计分析.结果表明,虽然各年级幼儿血铅浓度无显著差异,但是大、中班幼儿(4~6岁)由于受环境铅污染机会多于小班幼儿和托班幼儿,故血铅超标率稍高;幼儿经常挑食、外出方式以助力车或摩托车为主、家长经常吸烟、家长职业性接触铅及其化合物等是血铅浓度超标的主要因素. 相似文献
8.
In human patients, blood coagulation disorders often associate with cancer, even in its early stages. Recently, in vitro and in vivo experimental models have shown that oncogene expression, or inactivation of tumour suppressor genes, upregulate genes that
control blood coagulation. These studies suggest that activation of blood clotting, leading to peritumoral fibrin deposition,
is instrumental in cancer development. Fibrin can indeed build up a provisional matrix, supporting the invasive growth of
neoplastic tissues and blood vessels. Interference with blood coagulation can thus be considered as part of a multifaceted
therapeutic approach to cancer.
Received 30 November 2005; received after revision 7 February 2005; accepted 8 February 2006 相似文献
9.
李璞珉 《首都师范大学学报(自然科学版)》1991,(2)
本文运用了“内田-克列别林的耐力测查表”、“内曼(Ney-mann)和科尔斯太特(Kohlstedt)的内、外向性格调查表”,对400余名大学生的血型类别进行了测量,此外还运用了A型血和B型血的凝集反应时的测定方法进行了研究。结果表明,不同血型的大学生其行为有明显差异性,给学校管理人员和学生职业选择问题提出了参考意见。 相似文献
10.
Aldose reductase and aldehyde reductase belong to the aldo-keto reductase superfamily of enzymes whose members are responsible
for a wide variety of biological functions. Aldose reductase has been identified as the first enzyme involved in the polyol
pathway of glucose metabolism which converts glucose into sorbitol. Glucose over-utilization through the polyol pathway has
been linked to tissue-based pathologies associated with diabetes complications, which make the development of a potent aldose
reductase inhibitor an obvious and attractive strategy to prevent or delay the onset and progression of the complications.
Structural studies of aldose reductase and the homologous aldehyde reductase in complex with inhibitor were carried out to
explain the difference in the potency of enzyme inhibition. The aim of this review is to provide a comprehensive summary of
previous studies to aid the development of aldose reductase inhibitors that may have less toxicity problems than the currently
available ones.
Received 4 December 2006; received after revision 12 February 2007; accepted 20 April 2007 相似文献